Aarkstore Enterprise || Molecular Diagnostics Markets

The technologies that constitute molecular diagnostics-like first-generation amplification, DNA probes, fluorescent in situ hybridization (FISH), second-generation biochips and microfluidics, next-generation signal detection, biosensors, and molecular labels--are influencing the discovery of therapeutic molecules, the screening and diagnosis of patients, and the optimization of drug therapy. In the past few years, this rapidly evolving field has seen several fascinating developments. This Company Publications report describes the specific market segment of the in vitro diagnostics market known as molecular diagnostics and includes all of the generally accepted clinical analytical activities in use today. It examines the prevalent clinical-measurement devices, as well as their reagents and supplies as utilized in hospitals, clinics, large reference laboratories and doctor’s offices. Diagnostic tests marketed primarily as over-the-counter are generally not included in this report, although there is inevitably some overlap. The main objectives of this analysis are: 1) identifying viable technology drivers through a comprehensive look at platform technologies for molecular diagnostics, including probe-based nucleic acid assays, microarrays and sequencing; 2) obtaining a complete understanding of the chief molecular diagnostics tests-i.e., predictive, screening, prognostic, monitoring, pharmacogenomic and theranostic--from their basic principles to their applications; 3) discovering feasible market opportunities by identifying high-growth applications in different clinical diagnostic areas and by focusing on expanding markets, such as communicable diseases, cardiology and oncology; and 4) focusing on global industry development through an in-depth analysis of the major world markets for molecular diagnostics, including growth forecasts.
1. Overview 12
1.1 Statement of Report 12
1.2 About This Report 12
1.3 Scope of the Report 13
1.4 Objectives 13
1.5 Methodology 14
1.6 Executive Summary 15
2. Introduction to Molecular Diagnostics and PCR Technology 19
2.1 Introduction to Genomics and Its Opportunity 19
2.2 Impact of the Human Genome Project on Molecular Diagnostics 21
2.3 Key Considerations for Molecular Diagnostics 21
2.4 Molecular Diagnostics in the Post-Genomic Era 23
2.5 Advances in Molecular Diagnostics Technologies 24
2.6 Genetic Variability and Disease 25
2.7 Major Technology Platforms 25
2.7.1 Gene-based Amplification Technologies 28
2.7.2 Detection of Amplified Gene Products 28
2.7.3 Target-based Gene Amplification 29
2.7.3.1 Polymerase Chain Reaction (PCR) 29
2.7.3.2 Real-Time PCR 29
2.7.3.3 Nucleic Acid Sequence-based Amplification (NASBA) 30
2.7.4 Probe-based Amplification 30
2.7.4.1 Ligase Chain Reaction (LCR) 30
2.7.4.2 Strand Displacement Amplification (SDA) 31
2.7.4.3 QB-Replicase Amplified Probe Assay 31
2.7.5 Signal-based Amplification 31
2.7.5.1 Branched DNA (bDNA) 31
2.7.6 Other Gene Amplification Technologies 32
2.7.6.1 Immuno-PCR (IPCR) 32
2.7.6.2 Bio-Barcode Amplification Assay (BCA) 32
2.7.6.3 Hybrid Capture 33
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